HPE expands ProLiant servers & AI cloud with new NVIDIA GPUs
HPE has announced a series of updates to its NVIDIA AI Computing by HPE portfolio, emphasising expanded server capabilities and deeper integration with NVIDIA AI Enterprise solutions.
New server models
The HPE ProLiant Compute range will soon include servers featuring the NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs, available in a 2U form factor. Two main configurations will be available: the HPE ProLiant DL385 Gen11 server, supporting up to two of the new GPUs in a 2U chassis, and the previously announced HPE ProLiant Compute DL380a Gen12 server, capable of using up to eight GPUs in a 4U form factor. According to HPE, the latter configuration will be shipping in September.
These servers are designed for broad enterprise applications such as generative and agentic AI, robotics and industrial AI, visual computing (including autonomous vehicles and quality control monitoring), simulation, 3D modelling, digital twins, and enterprise applications. The HPE ProLiant Compute Gen12 servers also include hardware features aimed at enhancing security and operational efficiency, such as the HPE Integrated Lights Out (iLO) 7 Silicon Root of Trust and a secure enclave for tamper-resistant protection and quantum-resistant firmware signing.
HPE estimates that its Compute Ops Management, a cloud-native tool for managing server lifecycles, can decrease IT hours for server management by up to 75 percent and reduce downtime by approximately 4.8 hours per server each year.
HPE Private Cloud AI
HPE's Private Cloud AI offering, which has been co-developed with NVIDIA, is being updated to support the latest NVIDIA GPU technologies and AI models. The next version will offer compatibility for NVIDIA RTX PRO 6000 GPUs on Gen12 servers and aims to provide seamless scalability across different GPU generations. Features will include air-gapped management for security and support for enterprise multi-tenancy.
The new release of HPE Private Cloud AI will integrate recent NVIDIA AI models, including the NVIDIA Nemotron models focused on agentic AI, Cosmos Reason vision language model (VLM) for physical AI and robotics, and the NVIDIA Blueprint for Video Search and Summarization (VSS 2.4), intended to build video analytics AI agents that can process large volumes of video data. Customers will have access to these developments through the HPE AI Essentials platform, enabling the quick deployment of NVIDIA NIM microservices and other AI tools.
Through the continued collaboration, HPE Private Cloud AI is designed to deliver an integrated solution that leverages NVIDIA's portfolio in AI accelerated computing, networking, and software. This enables businesses to address increasing demand for AI inferencing and to accelerate the development and deployment of AI systems, maintaining high security and control over enterprise data.
Collaboration and customer impact
"HPE is committed to empowering enterprises with the tools they need to succeed in the age of AI," said Cheri Williams, senior vice president and general manager for private cloud and flex solutions at HPE. "Our collaboration with NVIDIA continues to push the boundaries of innovation, delivering solutions that unlock the value of generative, agentic and physical AI while addressing the unique demands of enterprise workloads. With the combination of HPE ProLiant servers and expanded capabilities in HPE Private Cloud AI, we're enabling organizations to embrace the future of AI with confidence and agility."
Justin Boitano, vice president of enterprise AI at NVIDIA, commented, "Enterprises need flexible, efficient infrastructure to keep pace with the demands of modern AI. With NVIDIA RTX PRO 6000 Blackwell GPUs in HPE's 2U ProLiant servers, enterprises can accelerate virtually every workload on a single, unified, enterprise-ready platform."
Availability
According to HPE, the HPE ProLiant DL385 Gen11 and HPE ProLiant Compute DL380a Gen12 servers featuring the NVIDIA RTX PRO 6000 Blackwell Server Edition GPUs are now orderable and are set for distribution worldwide beginning 2 September 2025.
Support within HPE Private Cloud AI for the latest NVIDIA Nemotron models, Cosmos Reason, and the NVIDIA Blueprint for VSS 2.4 is scheduled for release in the second half of 2025. The next generation of HPE Private Cloud AI with the updated GPU capabilities is also expected to be available during this period.
